Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure.

ABSTRACT: Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. We define exceptional EC (EEC) as HIV-1 subjects who maintain the EC characteristics without disease progression for more than 25 years. We analyzed three EEC, diagnosed between 1988 and 1992, who never showed signs of clinical disease progression in absence of any antiretroviral treatment. A comprehensive clinical, virological, and immunological study was performed. The individuals simultaneously exhibited ≥3 described host protective alleles, low levels of total HIV-1 DNA (<20 copies/10⁶ CD4⁺ T-cells) without evidence of replication-compete

SUBMITTER: Casado C 

PROVIDER: S-EPMC7002478 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature