Dataset Information

Foveal and parafoveal choroidal thickness pattern measuring by swept source optical coherence tomography.

ABSTRACT:

Objective

To evaluate the choroidal thickness (CT) in foveal and parafoveal regions in Thai adults using swept-source optical coherence tomography (SS-OCT).

Methods

We enrolled healthy volunteers ≥18 years of age from King Chulalongkorn Memorial Hospital, Thailand, during September 2015 to March 2016. Optical coherence tomography (OCT) of the macula was performed, and subfoveal CT was measured manually using a line scan. Average thicknesses of retinal and choroidal layers in regions of the Early Treatment Diabetic Retinopathy Study grid were measured automatically. A multivariate analysis was conducted to determine correlations between CTs in the foveal and parafoveal regions and retinal layers.

Results

Altogether, 144 eyes from 144 subjects (29 men, 115 women; mean age 41 years) were studied. The mean foveal CT was 282.4 ± 13.8 µm. It was thicker in the temporal fovea than in the nasal fovea (p < 0.001) and thicker in men than in women. Multivariate analysis showed that age and sex were significantly negatively correlated with the thickness of the retina, ganglion cell layer, outer retinal layer, and choroid but not of the nerve fiber layer. Regression analysis revealed that the CT decreased approximately 1.5 μm per year.

Conclusions

Age and sex significantly influence choroidal thickness. Macular CT in a healthy eye thins with age. CT decreases with age faster at distances away from the foveal center than at the center. Subfoveal CT was greater than the mean CT. Parafoveal CT should be evaluated to identify specific retinal-choroidal disease.

SUBMITTER: Pongsachareonnont P

PROVIDER: S-EPMC7002508 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Foveal and parafoveal choroidal thickness pattern measuring by swept source optical coherence tomography.

Pongsachareonnont Pear P Somkijrungroj Thanapong T Assavapongpaiboon Buravej B Chitamara Theerada T Chuntarapas Maytavee M Suwajanakorn Disorn D

Eye (London, England) 20190408 9

<h4>Objective</h4>To evaluate the choroidal thickness (CT) in foveal and parafoveal regions in Thai adults using swept-source optical coherence tomography (SS-OCT).<h4>Methods</h4>We enrolled healthy volunteers ≥18 years of age from King Chulalongkorn Memorial Hospital, Thailand, during September 2015 to March 2016. Optical coherence tomography (OCT) of the macula was performed, and subfoveal CT was measured manually using a line scan. Average thicknesses of retinal and choroidal layers in regio ...[more]

PMID: 30962543

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Project description:ObjectiveTo compare peripapillary and macular choroidal thickness (PCT and MCT) between open-angle glaucoma (OAG) and normal controls using swept-source optical coherence tomography (SS-OCT), and to evaluate global and localized relationships between choroidal thickness and various factors in OAG, also using SS-OCT.MethodsIn this cross-sectional comparative study, 134 OAG patients and 73 normal controls were examined. PCT (global, 12 clock-hour sectors), MCT (global, six sectors) were measured by SS-OCT. The difference in choroidal thickness between the OAG patients and the normal controls was analyzed. The relationships between choroidal thickness and various factors including age, sex, spherical equivalent (SE), axial length (AXL), central corneal thickness (CCT), intraocular pressure (IOP), peripapillary retinal nerve fiber layer thickness (pRNFLT), visual field mean deviation (MD), ganglion cell-inner plexiform layer thickness (GCIPLT), and disc area were analyzed by univariate and multivariate linear regression. Global and regional analyses were performed in 12 segments of the peripapillary circle and in six sectors of the macula.ResultsThere were significant differences in global PCT and MCT between the OAG patients and the normal controls (115.22±41.17 vs. 138.89±44.70, P<0.001), (184.36±57.15 vs. 209.25±61.11, P = 0.004). The difference in global PCT remained, both after adjusting for age, AXL (117.08±3.45 vs. 135.47±4.70, P = 0.002) and also after adjusting for age, AXL, disc area (117.46±3.46 vs. 135.67±4.67, P = 0.002). But the difference in global MCT did not remain after adjusting for age, AXL, SE (188.18±4.46 vs. 202.25±6.08, P = 0.066). PCT showed significant differences between the groups in all of the 12 clock-hour sectors. These differences remained after adjusting for age, AXL and for age, AXL, disc area, with the exception of the 10 o'clock (o/c) sector. MCT in six sectors showed differences between the two groups, but they did not remain after adjusting for age, AXL, SE. In a multivariate regression analysis of the OAG patients, global PCT showed correlations with age (β = -1.18, P = 0.001), AXL (β = -14.01, P<0.001), and disc area (β = -16.67, P = 0.026). Global MCT, meanwhile, showed a significant correlation with age (β = -1.92, P<0.001), AXL. (β = -21.97, P<0.001). Choroidal thickness did not show any global or localized relationship with glaucoma severity in the OAG patients.ConclusionsThe global and all 12 clock-hour PCT, with the exception of the 10 o/c sector, were thinner in OAG; however, they did not show any correlation with glaucoma severity. Possible roles of PCT in glaucoma pathogenesis should be investigated further.

Dataset Information

Foveal and parafoveal choroidal thickness pattern measuring by swept source optical coherence tomography.

Objective

Methods

Results

Conclusions

Publications

Foveal and parafoveal choroidal thickness pattern measuring by swept source optical coherence tomography.

Similar Datasets

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