Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya A
PROVIDER: S-EPMC7002723 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200205 1
Copy number alterations (CNAs) can promote tumor progression by altering gene expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not always translate proportionally into altered expression levels. By reanalyzing >34,000 gene expression profiles, we reveal the degree of transcriptional adaptation to CNAs in a genome-wide fashion, which strongly associate with distinct biological processes. We then develop a platform-independent method-transcriptional adaptation to CNA ...[more]