The intake of an extract from seeds of Tamarindus indica L. modulates the endocrine function of adult male mice under a high fat diet.

ABSTRACT: TBP is a natural product from Tamarindus indica L. seeds used as a natural remedy in India. This product is an antioxidant and may have beneficial effects on endocrine and metabolic functions. However, the regulatory mechanisms involved remain to be elucidated. In males, testosterone is synthesized by Leydig cells from the testis. With aging and obesity, testis function declines, leading to decreased testosterone synthesis. The aim of the current research is to determine how TBP improves testosterone production in male mice under a high fat diet leading to hypoandrogenic condition. Using C2C12 myoblast cells, we have found that TBP increased mitochondrial mass and oxygen respiration, as well as the production of the IGF-1 hormone. In addition, treatment of TM3 Leydig cells with TBP resulte

SUBMITTER: Cloutier F 

PROVIDER: S-EPMC7002859 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature