Partial hepatectomy‑induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration.

ABSTRACT: Following partial hepatectomy (PH), the complex process of liver regeneration is initiated, which encompasses the synchronized induction of hepatocyte proliferation. Hepatocyte proliferation can be regulated by multiple stimuli, including long non‑coding RNAs (lncRNAs) and Wnt/β‑catenin signaling, although the underlying mechanism of lncRNA/Wnt in liver regeneration remains unclear. In the present study, a liver regeneration‑associated functional lncRNA was identified, and its function was delineated in vitro and in vivo; lncRNA small nucleolar RNA host gene 12 (SNHG12) was revealed to be upregulated at various time‑points after 2/3 PH. The expression of SNHG12 was also increased in normal liver cell lines treated with different concentrations of hepatocyte growth factor (HGF). Functionall

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7003022 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature