Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice.

ABSTRACT: A high‑fat diet (HFD) or obesity‑promoting diet is closely associated with metabolic diseases and intestinal tumors, particularly in middle‑aged individuals (typically 45‑64 years old). The intestinal epithelium constitutes a barrier that separates the host from the food and microbiota in the gut, and thus, a dysfunctional epithelium is associated with a number of diseases. However, the changes caused to the function of intestinal epithelium in response to an HFD have not been well‑studied to date. In the present study, middle‑aged female mice (12 months old) fed an HFD for a period of 14 weeks were used to determine the effects of HFD on the intestine. Characteristics including the body weight, fat deposition, glucose metabolism, inflammatory state and intestinal morphology were assessed,

SUBMITTER: Xie Y 

PROVIDER: S-EPMC7003032 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature