Aspirin for primary prevention of stroke in individuals without cardiovascular disease-A meta-analysis.

ABSTRACT:

Background

The benefits of aspirin for primary prevention of stroke are uncertain.

Methods

We performed a cumulative meta-analysis of trials investigating aspirin for primary prevention of cardiovascular disease with a focus on stroke. We assessed the effects of aspirin on non-fatal stroke, hemorrhagic stroke, non-fatal myocardial infarction, all-cause mortality, cardiovascular mortality, major gastrointestinal bleeding, and an analysis of net clinical effect, in populations without a history of clinical or subclinical cardiovascular disease.

Summary of review results

Among 11 trials (157,054 participants), aspirin was not associated with a statistically significant reduction in non-fatal stroke (odds ratio, 0.94; 95% CI, 0.85 to 1.04) but was associated with an incre

SUBMITTER: Judge C 

PROVIDER: S-EPMC7003154 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature