Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype?

ABSTRACT: Transmissible spongiform encephalopathy (TSE) surveillance in goats relies on tests initially approved for cattle, subsequently assessed for sheep, and approval extrapolated for use in "small ruminants." The current EU-approved immunodetection tests employ antibodies against various epitopes of the prion protein PrP^Sc, which is encoded by the host PRNP gene. The caprine PRNP gene is polymorphic, mostly at codons different from the ovine PRNP. The EU goat population is much more heterogeneous than the sheep population, with more PRNP-related polymorphisms, and with marked breed-related differences. The ability of the current tests to detect disease-specific PrP^Sc generated against these different genetic backgrounds is currently assumed, rat

SUBMITTER: Simmons MM 

PROVIDER: S-EPMC7003235 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature