HbA1C Variability Is Strongly Associated with Development of Macroalbuminuria in Normal or Microalbuminuria in Patients with Type 2 Diabetes Mellitus: A Six-Year Follow-Up Study.

ABSTRACT:

Background

Glycemic variability is associated with higher risk of microvascular complications in patients with type 2 diabetes.

Aim

To test the hypothesis that glycemic variability can contribute to progression to macroalbuminuria in normal or microalbuminuria in patients with type 2 diabetes.

Design

This prospective study enrolled 193 patients with type 2 diabetes at a tertiary medical center.

Methods

For each patient, the intrapersonal glycemic variability (mean, SD, and coefficient of variation of HbA1c) was calculated using all measurements obtained three years before the study. Patients were divided into four groups stratified by both urine albumin/creatinine ratio and HbA1c-SD. The presence of macroalbuminuria was assessed with Kaplan-Meier plots and comp

SUBMITTER: Chiu WC 

PROVIDER: S-EPMC7003285 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature