BP Fluctuations and the Real-Time Dynamics of Renal Blood Flow Responses in Conscious Rats.

ABSTRACT:

Background

Renal autoregulation maintains stable renal function despite BP fluctuations and protects glomerular capillaries from hypertensive injury. However, real-time dynamics of renal autoregulation in conscious animals have not been characterized.

Methods

To develop novel analytic methods for assessing renal autoregulation, we recorded concurrent BP and renal blood flow in conscious rats, comparing animals with renal autoregulation that was intact versus impaired (from 3/4 nephrectomy), before and after additional impairment (from the calcium channel blocker amlodipine). We calculated autoregulatory indices for adjacent short segments of increasing length (0.5, 1, 2.5, 5, 10, and 20 seconds) that exhibited a mean BP difference of at least 5 mm Hg.

Results

Autoregu

SUBMITTER: Bidani AK 

PROVIDER: S-EPMC7003298 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature