Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort Study.

ABSTRACT:

Background

Sickle cell trait and sickle cell disease are thought to be independent risk factors for CKD, but the trajectory and predictors of kidney function decline in patients with these phenotypes are not well understood.

Methods

Our multicenter, observational study used registry data (collected January 2005 through June 2018) and included adult black patients with sickle cell trait or disease (exposures) or normal hemoglobin phenotype (reference) status (ascertained by electrophoresis) and at least 1 year of follow-up and three eGFR values. We used linear mixed models to evaluate the difference in the mean change in eGFR per year.

Results

We identified 1251 patients with sickle cell trait, 230 with sickle cell disease, and 8729 reference patients, with a median fo

SUBMITTER: Olaniran KO 

PROVIDER: S-EPMC7003305 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature