Stakeholder views on the acceptability of human infection studies in Malawi.

ABSTRACT: BACKGROUND:Human infection studies (HIS) are valuable in vaccine development. Deliberate infection, however, creates challenging questions, particularly in low and middle-income countries (LMICs) where HIS are new and ethical challenges may be heightened. Consultation with stakeholders is needed to support contextually appropriate and acceptable study design. We examined stakeholder perceptions about the acceptability and ethics of HIS in Malawi, to inform decisions about planned pneumococcal challenge research and wider understanding of HIS ethics in LMICs. METHODS:We conducted 6 deliberative focus groups and 15 follow-up interviews with research staff, medical students, and community representatives from rural and urban Blantyre. We also conducted 5 key informant interviews with clinicia

SUBMITTER: Kapumba BM 

PROVIDER: S-EPMC7003337 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature