Bone health in symptomatic carriers of haemophilia A: a protocol for a multicentre prospective matched-cohort study.

ABSTRACT:

Introduction

Haemophilia A is an X linked inherited bleeding disorder, caused by a decrease in coagulation factor VIII. Persons with haemophilia experience repeated musculoskeletal bleeding, which can lead to decreased range of motion, irreversible joint damage, low bone mineral density (BMD), and are at greater risk for osteoporosis. Women heterozygous for this mutation, also known as haemophilia A carriers, can have bleeding symptoms and even experience joint bleeding evidenced by radiological soft tissue and osteochondral changes. The prevalence of low BMD as a risk factor for osteoporosis has never been evaluated in carriers of haemophilia, and given the recent findings which suggest subclinical musculoskeletal bleeding in carrier women, we hypothesise that they too are at risk

SUBMITTER: Tang GH 

PROVIDER: S-EPMC7003383 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature