Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population.

ABSTRACT:

Background

Postoperative inadequate analgesia following video-assisted thoracoscopic surgery (VATS) is a common and significant clinical problem. While genetic polymorphisms may play role in the variability of postoperative analgesia effect, few studies have evaluated the associations between genetic mutations and inadequate analgesia after single-port VATS.

Methods

Twenty-eight single nucleotide polymorphisms (SNPs) among 18 selected genes involved in pain perception and modulation were genotyped in 198 Chinese patients undergoing single-port VATS. The primary outcome was the occurrence of inadequate analgesia in the first night and morning after surgery which was defined by a comprehensive postoperative evaluation. Multivariable logistic regression analyses were used to id

SUBMITTER: Xing X 

PROVIDER: S-EPMC7003404 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature