Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives.

ABSTRACT: In the present work we modified the procedure for isolation of naphthoquinones α-methylbutyrylshikon ( 1 ), acetylshikonin ( 2 ) and β-hydroxyisovalerylshikonin ( 3 ) from Onosma visianii Clem. We also investigated possible mechanisms of 1 , 2 and 3 as antitumor agents. Accordingly, we estimated concentrations of superoxide anion radical (O₂ ^.-), nitrite (NO₂ ^-) and glutathione in HCT-116 and MDA-MB-231 cell lines. Compounds 1 and 3 expressed significant prooxidative activity, while all tested compounds exhibited significant increase in nitrite levels. Also, all examined compounds significantly increased the concentration

SUBMITTER: Vukic MD 

PROVIDER: S-EPMC7003638 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature