Patterns of recurrence and metastasis in BRCA1/BRCA2-associated breast cancers.

ABSTRACT:

Background

Breast cancer subtypes are associated with distinct metastatic patterns. Whether germline BRCA1/BRCA2 mutation status is independently associated with central nervous system (CNS) relapse, controlling for tumor subtype, is unknown.

Methods

Patients who were treated at Dana-Farber Cancer Institute and diagnosed with a first locoregional recurrence (LRR) or metastasis between 1981 and 2014 were identified using 2 institutional registries: 1) patients treated for recurrent breast cancer and 2) patients who underwent BRCA testing. The frequencies of LRR, sites of metastasis, and breast cancer-specific survival from LRR or metastasis were calculated, and the factors associated with CNS recurrence were evaluated using multivariable logistic regression models.

Results

SUBMITTER: Song Y 

PROVIDER: S-EPMC7003745 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature