Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common cancer diagnosis in the Western world.

Aim

To evaluate exhaled volatile organic compounds (VOCs) as a non-invasive biomarker for the detection of CRC and precursor lesions using an electronic nose.

Methods

In this multicentre study adult colonoscopy patients, without inflammatory bowel disease or (previous) malignancy, were invited for breath analysis. Two-thirds of the breath tests were randomly assigned to develop training models which were used to predict the diagnosis of the remaining patients (external validation). In the end, all data were used to develop final-disease models to further improve the discriminatory power of the algorithms.

Results

Five hundred and eleven breath samples were collect

SUBMITTER: van Keulen KE 

PROVIDER: S-EPMC7003780 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature