Heterogeneous Temporal Contrast Adaptation in Drosophila Direction-Selective Circuits.

ABSTRACT: In visual systems, neurons adapt both to the mean light level and to the range of light levels, or the contrast. Contrast adaptation has been studied extensively, but it remains unclear how it is distributed among neurons in connected circuits, and how early adaptation affects subsequent computations. Here, we investigated temporal contrast adaptation in neurons across Drosophila's visual motion circuitry. Several ON-pathway neurons showed strong adaptation to changes in contrast over time. One of these neurons, Mi1, showed almost complete adaptation on fast timescales, and experiments ruled out several potential mechanisms for its adaptive properties. When contrast adaptation reduced the gain in ON-pathway cells, it was accompanied by decreased motion responses in downstream direction-sel

SUBMITTER: Matulis CA 

PROVIDER: S-EPMC7003801 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature