Compromised CD4:CD8 ratio recovery in people living with HIV aged over 50 years: an observational study.

ABSTRACT:

Objectives

Persistent CD4:CD8 ratio inversion (< 1) is associated with mortality in older people. We investigated the interaction of the effects of baseline CD8 count and age at HIV diagnosis on CD4:CD8 ratio recovery with antiretroviral therapy (ART).

Methods

An observational study (1 January 2007 to 31 December 2016) was carried out using routinely collected data from the HIV outpatient services at Imperial College Healthcare NHS Trust, London, UK. CD4 and CD8 counts, prior to and during ART, treatment during primary HIV infection (PHI) and HIV-1 viral load were included in univariate and multivariate analyses using Cox proportional hazard regression.

Results

Data were included for 876 patients starting ART, where HIV suppression was achieved. Of these patients, 741

SUBMITTER: Francis-Morris A 

PROVIDER: S-EPMC7003811 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature