Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank.

ABSTRACT:

Objective

To examine the association between the MTNR1B G risk allele, type 2 diabetes (T2D) and chronotype in the UK Biobank.

Methods

Data from the baseline investigation of the UK Biobank were utilized (n = 337 083 White British; mean age: 56.9 years; 54% women). MTNR1B rs10830963 was directly genotyped [CC (reference group), CG and GG]. Chronotype was divided into four categories: definitely morning (reference group); more morning than evening; more evening than morning; and definitely evening. Logistic regression analyses were performed to estimate odds ratios and 95% confidence intervals (CIs) for T2D, controlling for age, sex and other confounders.

Results

Carriers of the rs10830963 risk allele had a higher risk of T2D [CG vs. CC: OR (95% CI) 1.10 (1.07, 1.15);

SUBMITTER: Tan X 

PROVIDER: S-EPMC7003850 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature