Migraine Genetic Variants Influence Cerebral Blood Flow.

ABSTRACT:

Objective

To investigate the association of migraine genetic variants with cerebral blood flow (CBF).

Background

Migraine is a common disorder with many genetic and non-genetic factors affecting its occurrence. The exact pathophysiological mechanisms underlying the disease remain unclear, but are known to involve hemodynamic and vascular disruptions. Recent genome-wide association studies have identified 44 genetic variants in 38 genetic loci that affect the risk of migraine, which provide the opportunity to further disentangle these mechanisms.

Methods

We included 4665 participants of the population-based Rotterdam Study (mean age 65.0 ± 10.9 years, 55.6% women). Cross-sectional area (mm² ), flow velocity (mm/s), and blood flow (mL/min) were measured in bo

SUBMITTER: Knol MJ 

PROVIDER: S-EPMC7003871 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature