A quantitative assessment of the dynamic modification of lipid-DNA probes on live cell membranes.

ABSTRACT: Synthetic lipid-DNA probes have recently attracted much attention for cell membrane analysis, transmembrane signal transduction, and regulating intercellular networks. These lipid-DNA probes can spontaneously insert onto plasma membranes simply after incubation. The highly precise and controllable DNA interactions have further allowed the programmable manipulation of these membrane-anchored functional probes. However, we still have quite limited understanding of how these lipid-DNA probes interact with cell membranes and also what parameters determine this process. In this study, we have systematically studied the dynamic process of cell membrane modification with a group of lipid-DNA probes. Our results indicated that the hydrophobicity of the lipid-DNA probes is strongly correlated with

SUBMITTER: Bagheri Y 

PROVIDER: S-EPMC7003967 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature