PEGylated reduced-graphene oxide hybridized with Fe₃O₄ nanoparticles for cancer photothermal-immunotherapy.

ABSTRACT: Photoimmunotherapy has attracted much attention recently for the treatment of metastatic tumors. The development of smart nanocomposites for imaging-guided therapies is needed to improve the efficacy of cancer treatment. Herein, a PEGylated nanocomposite was developed for photothermal-immunotherapy. In particular, this nanocomposite was formulated by hybridizing Fe₃O₄ nanoparticles (FNPs) with reduced-graphene oxide (rGO) through electrostatic interaction, modified by PEG-NH₂ on the surface of FNPs/rGO. The FNPs/rGO-PEG nanocomposites are excellent agents for photothermal therapy (PTT) under irradiation by an 805 nm laser. This nanocomposite could promote the activity of the host antitumor immune response efficiently because of the reduction of tumor-associ

SUBMITTER: Wang L 

PROVIDER: S-EPMC7003986 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature