The impact of current treatment modalities on the outcomes of patients with melanoma brain metastases: A systematic review.

ABSTRACT: Patients with melanoma brain metastases (MBM) still have a very poor prognosis. Several treatment modalities have been investigated in an attempt to improve the management of MBM. This review aimed to evaluate the impact of current treatments for MBM on patient- and tumor-related outcomes, and to provide treatment recommendations for this patient population. A literature search in the databases PubMed, Embase, Web of Science and Cochrane was conducted up to January 8, 2019. Original articles published since 2010 describing patient- and tumor-related outcomes of adult MBM patients treated with clearly defined systemic therapy were included. Information on basic trial demographics, treatment under investigation and outcomes (overall and progression-free survival, local and distant control an

SUBMITTER: van Opijnen MP 

PROVIDER: S-EPMC7004107 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature