Placental growth factor blunts uterine artery responses to angiotensin II.

ABSTRACT:

Objective

Changes in maternal serum concentration of placental growth factor (PlGF) and vascular response to intravascular infusion of Angiotensin II (Ang II) follow a bell-shaped curve pattern during gestation. This study evaluates the effects of PlGF and soluble vascular endothelial growth factor receptor-1 (sFlt-1) on responses of human uterine arteries (UA) to Ang II.

Design

Experimental.

Setting

Baylor College of Medicine and Texas Children's Hospital-Pavilion for Women.

Sample

Uterine arteries samples (n = 14) were obtained from normotensive women undergoing caesarean hysterectomy at ≥32 weeks.

Methods

Uterine arteries rings were incubated with (1) Krebs solution; (2) PlGF at 1.45, 14.5, and 500 pg/ml; (3) sFlt-1 at 2 ng/ml; and (4) a combination o

SUBMITTER: Espinoza J 

PROVIDER: S-EPMC7004274 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature