Recent Advances in the Development of Integrase Inhibitors for HIV Treatment.

ABSTRACT:

Purpose of the review

The complex multistep life cycle of HIV allows it to proliferate within the host and integrate its genome in to the host chromosomal DNA. This provirus can remain dormant for an indefinite period. The process of integration, governed by integrase (IN), is highly conserved across the Retroviridae family. Hence, targeting integration is not only expected to block HIV replication but may also reveal new therapeutic strategies to treat HIV as well as other retrovirus infections.

Recent findings

HIV integrase (IN) has gained attention as the most promising therapeutic target as there are no equivalent homologues of IN that has been discovered in humans. Although current nano-formulated long-acting IN inhibitors have demonstrated the phenomenal ability to blo

SUBMITTER: Trivedi J 

PROVIDER: S-EPMC7004278 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature