Unraveling the role of salt-sensitivity genes in obesity with integrated network biology and co-expression analysis.

ABSTRACT: Obesity is a multifactorial disease caused by complex interactions between genes and dietary factors. Salt-rich diet is related to the development and progression of several chronic diseases including obesity. However, the molecular basis of how salt sensitivity genes (SSG) contribute to adiposity in obesity patients remains unexplored. In this study, we used the microarray expression data of visceral adipose tissue samples and constructed a complex protein-interaction network of salt sensitivity genes and their co-expressed genes to trace the molecular pathways connected to obesity. The Salt Sensitivity Protein Interaction Network (SSPIN) of 2691 differentially expressed genes and their 15474 interactions has shown that adipose tissues are enriched with the expression of 23 SSGs, 16 hubs

SUBMITTER: Sabir JSM 

PROVIDER: S-EPMC7004317 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature