Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles.

ABSTRACT:

Introduction

Adverse drug reactions have been linked with HLA alleles in different studies. These HLA proteins play an essential role in the adaptive immune response for the presentation of self and non-self peptides. Anti-thyroid drugs methimazole and propylthiouracil have been associated with drug induced agranulocytosis (severe lower white blood cell count) in patients with B*27:05, B*38:02 and DRB1*08:03 alleles in different populations: Taiwanese, Vietnamese, Han Chinese and Caucasian.

Methods

In this study, informatics methods were used to investigate if any sequence or structural similarities exist between the two associated HLA-B alleles, compared with a set of "control" alleles assumed not be associated, which could help explain the molecular basis of the adverse dr

SUBMITTER: Ramsbottom KA 

PROVIDER: S-EPMC7004376 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature