Agricultural and geographic factors shaped the North American 2015 highly pathogenic avian influenza H5N2 outbreak.

ABSTRACT: The 2014-2015 highly pathogenic avian influenza (HPAI) H5NX outbreak represents the largest and most expensive HPAI outbreak in the United States to date. Despite extensive traditional and molecular epidemiological studies, factors associated with the spread of HPAI among midwestern poultry premises remain unclear. To better understand the dynamics of this outbreak, 182 full genome HPAI H5N2 sequences isolated from commercial layer chicken and turkey production premises were analyzed using evolutionary models able to accommodate epidemiological and geographic information. Epidemiological compartmental models embedded in a phylogenetic framework provided evidence that poultry type acted as a barrier to the transmission of virus among midwestern poultry farms. Furthermore, after initial intr

SUBMITTER: Hicks JT 

PROVIDER: S-EPMC7004387 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature