Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer.

ABSTRACT: Metabolic reprogramming, including the Warburg effect, is a hallmark of cancer. Indeed, the diversity of cancer metabolism leads to cancer heterogeneity, but accurate assessment of metabolic properties in tumors has not yet been undertaken. Here, we performed absolute quantification of the expression levels of 113 proteins related to carbohydrate metabolism and antioxidant pathways, in stage III colorectal cancer surgical specimens from 70 patients. The Warburg effect appeared in absolute protein levels between tumor and normal mucosa specimens demonstrated. Notably, the levels of proteins associated with the tricarboxylic citric acid cycle were remarkably reduced in the malignant tumors which had relapsed after surgery and treatment with 5-fluorouracil-based adjuvant therapy. In addition,

SUBMITTER: Kitazawa M 

PROVIDER: S-EPMC7004516 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature