Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma.

ABSTRACT: The tripartite motif containing 23 (TRIM23) gene is a member of the tripartite motif (TRIM) family that participates in many pathophysiological processes. However, the role of TRIM23 in lung adenocarcinoma (LUAD) remains unclear. In the present study, TRIM23 was first screened by next-generation sequencing between the cisplatin (DDP)-resistant A549/DDP cell line and the parental A549 cell line, combined with integrated analysis of the Gene Expression Omnibus (GEO) data (E-GEOD-43493 and E-GEOD-43494). The expression of TRIM23 was then verified to be upregulated in the DDP-resistant LUAD cells and tissues. The knockdown of TRIM23 expression in A549/DDP cells caused increased apoptosis, decreased IC₅₀ values of DDP, NF-κB nuclear translocation, inhibition of cell proliferation in

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7004530 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature