Spatial and temporal expansion of intrahepatic metastasis by molecularly-defined clonality in multiple liver cancers.

ABSTRACT: Multiple hepatocellular carcinoma (HCC) is divided into two categories: intrahepatic metastasis (IM), which is a true relapse of HCC, and multicentric origin (MO), which is a second primary tumor. Clinical diagnosis of multiple HCC is usually made based on tumor location and/or time to recurrence; however, it is often difficult to distinguish the two types of multiple HCC. Using 41 matched pairs of multiple HCC specimens, we confirmed the accuracy of clinical diagnoses using exome sequence data and investigated the importance of discriminating the type of multiple HCC. Genomic analysis revealed that 18 (43.9%) patients diagnosed as having genomic IM had common mutations in a pair of HCC tumors with the main tumor of these patients being more progressive compared to those with genomic MO. T

SUBMITTER: Yamamoto S 

PROVIDER: S-EPMC7004543 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature