Effect of alkaline phosphatase on sepsis-associated acute kidney injury patients: A systematic review and meta-analysis.

ABSTRACT:

Background

This systematic review and meta-analysis were performed to evaluate kidney function in patients with sepsis-associated acute kidney injury (SA-AKI) on alkaline phosphatase (AP) therapy.

Methods

PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched electronically from inception until May 4, 2019 and randomized controlled studies assessing AP treatment in patients with SA-AKI were included. Pool analyses with fixed effects or random effects models calculated pooled mean, standard deviation, and odds ratio (OR) with 95% confidence interval (CI).

Results

Four randomized controlled trials involving AP therapy for 392 patients with SA-AKI were included. AP had a positive effect on endogenous creatinine clearance (ECC) in patients wi

SUBMITTER: Tang W 

PROVIDER: S-EPMC7004577 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature