Establishment of a new formula for QT interval correction using a large colony of cynomolgus monkeys.

ABSTRACT: The demand for monkeys for medical research is increasing, because their ionic mechanism of repolarization is similar to that of humans. The QT interval is the distance between the Q wave and T wave, but this interval is affected by heart rate. Therefore, QT correction methods are commonly used in clinical settings. However, an accurate correction formula for the QT interval in cynomolgus monkeys has not been reported. We assessed snapshot electrocardiograms (ECGs) of 353 ketamine-immobilized monkeys, including aged animals, and contrived a new formula for the corrected QT interval (QTc) as a marker of QT interval prolongation in cynomolgus monkeys. Values for QTc were calculated using the formula [QTc] = [QT] / [RR]ⁿ, along with several other formulas commonly used to calculate

SUBMITTER: Nakayama S 

PROVIDER: S-EPMC7004807 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature