Ontology highlight
ABSTRACT:
SUBMITTER: Bensard CL
PROVIDER: S-EPMC7004878 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell metabolism 20191205 2
Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import. Genetic studies in Drosophila suggest that this downr ...[more]