Optical Coherence Elastography-Based Corneal Strain Imaging During Low-Amplitude Intraocular Pressure Modulation.

ABSTRACT: Purpose: Optical coherence elastography (OCE) is a promising technique for high-resolution strain imaging in ocular tissues. A major strain-inducing factor in the eye is intraocular pressure (IOP), with diurnal physiological fluctuations reaching up to 5 mmHg. We study herein low-amplitude IOP modulation to assess local corneal strain patterns. Methods: Ex vivo porcine eye globes were adjusted to an initial IOP of 15 mmHg and subsequently 25 mmHg. Corneal strain was induced by two subsequent pressure cycles, in which IOP was first increased and then decreased, each by a total of 5 mmHg. Two-dimensional optical coherence tomography (2D-OCT) B-scans were recorded after each loading step. Axial strain maps were obtained from magnitude and phase changes and supra-pixel displacements from cross

SUBMITTER: Kling S 

PROVIDER: S-EPMC7004960 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature