Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption.

ABSTRACT: Protein hydrolysates are an important part of the human diet. Often, they are prepared from milk, soy, or collagen. In the present study, four different collagen hydrolysates were tested, varying in the average molecular weight and the animal source. Three types of samples, the dissolved start products, in vitro generated dialysates (containing the digested components that are potentially available for small intestinal absorption), and human serum collected after product ingestion, were analyzed using LC-MS to compare the state of the hydrolysates before and after absorption, i.e., uptake into the blood. It was found that the composition of the collagen hydrolysates prior to and after ingestion was highly complex and dynamic, which made it challenging to predefine a strategy for a targeted

SUBMITTER: Kleinnijenhuis AJ 

PROVIDER: S-EPMC7005076 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature