Three-dimensional analysis of the thoracic aorta microscopic deformation during intraluminal pressurization.

ABSTRACT: The aorta is composed of various constituents with different mechanical properties. This heterogeneous structure implies non-uniform deformation in the aorta, which could affect local cell functions. The present study investigates 3D strains of the aorta at a cell scale induced by intraluminal pressurization. After resected mouse, thoracic aortas were stretched to their in vivo length, and the aortas were pressurized at 15, 40, 80, 120, and 160 mmHg. Images of autofluorescent light of elastin were captured under a two-photon microscope. From the movement of markers in elastic laminas (ELs) created by photo-bleaching, 3D strains (ε_θθ, ε_zz, ε_rr, ε_rθ, ε_rz, ε_θz) between two neighboring ELs in the circumferential (θ), longitudina

SUBMITTER: Sugita S 

PROVIDER: S-EPMC7005079 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature