A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues.

ABSTRACT: Mathematical models are increasingly designed to guide experiments in biology, biotechnology, as well as to assist in medical decision making. They are in particular important to understand emergent collective cell behavior. For this purpose, the models, despite still abstractions of reality, need to be quantitative in all aspects relevant for the question of interest. This paper considers as showcase example the regeneration of liver after drug-induced depletion of hepatocytes, in which the surviving and dividing hepatocytes must squeeze in between the blood vessels of a network to refill the emerged lesions. Here, the cells' response to mechanical stress might significantly impact the regeneration process. We present a 3D high-resolution cell-based model integrating information from meas

SUBMITTER: Van Liedekerke P 

PROVIDER: S-EPMC7005086 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature