Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria.

ABSTRACT: Streptomyces bacteria are known for their prolific production of secondary metabolites, many of which have been widely used in human medicine, agriculture and animal health. To guide the effective prioritization of specific biosynthetic gene clusters (BGCs) for drug development and targeting the most prolific producer strains, knowledge about phylogenetic relationships of Streptomyces species, genome-wide diversity and distribution patterns of BGCs is critical. We used genomic and phylogenetic methods to elucidate the diversity of major classes of BGCs in 1,110 publicly available Streptomyces genomes. Genome mining of Streptomyces reveals high diversity of BGCs and variable distribution patterns in the Streptomyces phylogeny, even among very closely related strains. The most common BGCs ar

SUBMITTER: Belknap KC 

PROVIDER: S-EPMC7005152 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature