Manganese-enhanced T₁ mapping to quantify myocardial viability: validation with ¹⁸F-fluorodeoxyglucose positron emission tomography.

ABSTRACT: Gadolinium chelates are widely used in cardiovascular magnetic resonance imaging (MRI) as passive intravascular and extracellular space markers. Manganese, a biologically active paramagnetic calcium analogue, provides novel intracellular myocardial tissue characterisation. We previously showed manganese-enhanced MRI (MEMRI) more accurately quantifies myocardial infarction than gadolinium delayed-enhancement MRI (DEMRI). Here, we evaluated the potential of MEMRI to assess myocardial viability compared to gold-standard ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) viability. Coronary artery ligation surgery was performed in male Sprague-Dawley rats (n = 13) followed by dual MEMRI and ¹⁸F-FDG PET imaging at 10-12 weeks. MEMRI was achieved

SUBMITTER: Spath N 

PROVIDER: S-EPMC7005182 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature