Two Novel Loci of RELN Associated With Antipsychotics Response in Chinese Han Population.

ABSTRACT:

Background

There are great individual differences in the drug responses; however, there are few prognostic drug response biomarkers available. RELN is one of the more extensively examined schizophrenia candidate genes. The purpose of this study was to determine whether RELN can affect antipsychotics response in the Chinese population. This may lead to the discovery of relevant novel drug response markers.

Methods

The unrelated 260 Chinese Han inpatients with schizophrenia were enrolled in the present study. The enrolled subjects have been prescribed antipsychotic medication during the study. A total of 15 SNPs of RELN were genotyped by MassARRAY^® platform. The association of the RELN gene with therapeutic response to antipsychotics was

SUBMITTER: Xu Q 

PROVIDER: S-EPMC7005197 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature