Deep Eutectic Solvents as Media for the Prebiotic DNA-Templated Synthesis of Peptides.

ABSTRACT: Translation of genetic information into peptide products is one of the fundamental processes of biology. How this occurred prebiotically, in the absence of enzyme catalysts, is an intriguing question. Nucleic acid-templated synthesis (NATS) promotes reactions by bringing building blocks tethered to complementary DNA strands into close proximity and has been shown to enable peptide synthesis without enzymes-it could therefore serve as a model for prebiotic translation of information stored in nucleic acid sequences into functional peptides. The decomposition of highly reactive DNA adapters has so far limited the effectiveness of NATS, but these studies have been performed exclusively in aqueous solution. Deep eutectic solvents (DESs) have been proposed as a feasible solvent for prebiotic re

SUBMITTER: Nunez-Pertinez S 

PROVIDER: S-EPMC7005209 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature