Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants.

ABSTRACT:

Importance

The recent implication of 108 genomic loci in schizophrenia marked a great advancement in our understanding of the disease. Against the background of its polygenic nature there is a necessity to identify how schizophrenia risk genes interplay. As regulators of gene expression, microRNAs (miRNAs) have repeatedly been implicated in schizophrenia etiology. It is therefore of interest to establish their role in the regulation of schizophrenia risk genes in disease-relevant biological processes.

Objective

To examine the role of miRNAs in schizophrenia in the context of disease-associated genetic variation.

Design, setting, and participants

The basis of this study was summary statistics from the largest schizophrenia genome-wide association study meta-analysis to

SUBMITTER: Hauberg ME 

PROVIDER: S-EPMC7005318 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature