Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.

ABSTRACT: Mechanisms mediating the protective effects of molecular hydrogen (H₂) are not well understood. This study explored the possibility that H₂ exerts its anti-inflammatory effect by modulating energy metabolic pathway switch. Activities of glycolytic and mitochondrial oxidative phosphorylation systems were assessed in asthmatic patients and in mouse model of allergic airway inflammation. The effects of hydrogen treatment on airway inflammation and on changes in activities of these two pathways were evaluated. Monocytes from asthmatic patients and lungs from ovalbumin-sensitized and challenged mice had increased lactate production and glycolytic enzyme activities (enhanced glycolysis), accompanied by decreased ATP production and mitochondrial respiratory chain complex I a

SUBMITTER: Niu Y 

PROVIDER: S-EPMC7005324 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature