Human iPSC-Derived Neural Crest Stem Cells Exhibit Low Immunogenicity.

ABSTRACT: Recent clinical trials are evaluating induced pluripotent stem cells (iPSCs) as a cellular therapy in the field of regenerative medicine. The widespread clinical utility of iPSCs is expected to be realized using allogeneic cells that have undergone thorough safety evaluations, including assessment of their immunogenicity. IPSC-derived neural crest stem cells (NCSCs) have significant potential in regenerative medicine; however, their application in cellular therapy has not been widely studied to date, and no reports on their potential immunogenicity have been published so far. In this study, we have assessed the expression of immune-related antigens in iPSC-NCSCs, including human leukocyte antigen (HLA) class I and II and co-stimulatory molecules. To investigate functional immunogenicity, w

SUBMITTER: Mehler VJ 

PROVIDER: S-EPMC7005462 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature