Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

ABSTRACT: Dementia with Lewy bodies (DLB) is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer's pathology. Neuroinflammation is also increasingly recognized as a significant contributor to degeneration. We aimed to examine the relationship between microglial activation as measured with [¹¹C]-PK11195 brain PET, MR diffusion tensor imaging (DTI) and grey matter atrophy in DLB. Nineteen clinically probable DLB and 20 similarly aged controls underwent 3T structural MRI (T1-weighted) and diffusion-weighted imaging. Eighteen DLB subjects also underwent [¹¹C]-PK11195 PET imaging and 15 had [¹¹C]-Pittsburgh compound B amyloid PET, resulting in 9/15 being amyloid-positive. We used Computational Anatomy Toolbox (CAT12) for volume

SUBMITTER: Nicastro N 

PROVIDER: S-EPMC7005463 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature