Body composition predicts mortality and decompensation in compensated cirrhosis patients: A prospective cohort study.

ABSTRACT:

Background & aims

Body composition, particularly sarcopenia, is associated with mortality in patients with decompensated cirrhosis undergoing transplant evaluation. Similar data are limited for non-transplant eligible or compensated patients.

Methods

A total of 274 patients with cirrhosis were followed prospectively for ≤5 years after a CT scan. We utilized Analytic Morphomics® to measure body composition (fat, muscle, and bone) which was rendered into relative values (percentiles) in relation to a reference population. The model for end-stage liver disease (MELD) score was used as a reference model for survival prediction. We validated our models in a separate cohort.

Results

Our cohort had a mean Child-Pugh score of 7.0 and a mean MELD of 11.3. The median follow-up

SUBMITTER: Tapper EB 

PROVIDER: S-EPMC7005567 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature