Monitoring treatment efficacy and resistance in breast cancer patients via circulating tumor DNA genomic profiling.

ABSTRACT:

Background

One of the major challenges in managing invasive breast cancer (BC) is the lack of reliable biomarkers to track response. Circulating tumor DNA (ctDNA) from liquid biopsy, as a candidate biomarker, provides a valuable assessment of BC patients. In this retrospective study, we evaluated the utility of ctDNA to reflect the efficacy of treatment and to monitor resistance mechanisms.

Methods

Targeted next-generation sequencing (NGS) of 416 cancer-relevant genes was performed on 41 plasma biopsy samples of 19 HER2+ and 12 HER2- BC patients. Longitudinal ctDNA samples were analyzed in three BC patients over the treatment course for detecting acquired mutations.

Results

In HER2+ BC patients, ERBB2 somatic copy numbers in ctDNA samples were significantly higher in

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7005625 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature