Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis.

ABSTRACT:

Background & aims

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive inflammatory and fibrotic injury to the biliary tree. We sought to further delineate the contribution of macrophage lineages in PSC pathobiology.

Methods

Human liver tissues and/or blood samples from patients with PSC, primary biliary cholangitis, other non-cholestatic/non-autoimmune diseases, including alcohol-related liver disease and non-alcoholic steatohepatitis, as well as normal liver, were sourced from our liver transplantation program. Liver fibrosis was studied using Van Gieson staining, while the frequencies of infiltrating monocyte and macrophage lineages, both in the circulation and the liver, were investigated by flow cytometry, including th

SUBMITTER: Chen YY 

PROVIDER: S-EPMC7005651 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature